Following the example of the world's prestigious universities, PSL has its own symphony orchestra and choir, the OCPSL. Open to all students and staff of PSL University, the association's repertoire reflects its image: eclectic, innovative, original, and composed of varied styles of music (classical repertoire and forgotten or contemporary composers, jazz and gospel, musicals).

The association Musique @ Paris sciences et lettres aims to organize the musical season of the PSL Orchestra and Choir and the PSL Spring Festival. It is an association law 1901, and employs a team of entertainment professionals to supervise the various musical formations from an artistic and technical point of view. The OCPSL is a choro-symphonic ensemble of 150 musicians and singers who regularly perform in prestigious venues in the capital or abroad during international tours. Its two components are the PSL Symphony Orchestra and the PSL Grand Chœur.

Thesymphony orchestra is conducted by Johan Farjot alongside the support of an intermittent team of three great professional musicians providing administrative supervision, notabily Arnaud Thorette on the first violin, Béatrice Muthelet on the viola and Antoine Pierlot on the cello. Students, professors and members of staff from the grandes écoles, universities and establishments of PSL make up the 75 members of the orchestra, all of whom were selected by audition. Soloists of international stature are also regularly invited, thereby offering students the opportunity to connect with big names in musical interpretation.

The Great Choir of PSL is also directed by Johan Farjot, and is assisted by pianist and vocal coach Julien Rezak. It is mainly composed of 80 amateur choristers selected by audition (students, professors and members of staff from the Grandes Ecoles of PSL University). In addition to its own musical programs ans tours, the choir is in partnership with the Orchester symphonique PSL under the choro-symphonic ensemble OCPSL, The Choir also regularly collaborates with other prestigious formations such as the Orchestre de la Garde Républicaine or international choral formations. (Robinson College Chapel Choir – University of Cambridge, City-University of London, ensemble Gaudeamus de Sophia…)